The spread of coronavirus in the body captured on video

The spread of coronavirus in the body captured on video
The spread of coronavirus in the body captured on video
Anonim

For the first time, researchers from the United States and Canada were able to capture in real time how the coronavirus infection spreads through the body of a mouse. An article by scientists was published in the journal Immunity, a video of the spread of the virus was published on Youtube.

To track the spread of SARS-CoV-2 at the cellular level, researchers at the Universities of Montreal and Yale used bioluminescent tags and advanced microscopy techniques. The way the coronavirus spreads in mice is similar to how the infection develops in humans: first, the virus entered the nose, multiplied there and spread through the lungs. On the third day after infection, SARS-CoV-2 began to penetrate into other organs. Then he got to the brain, after which the mice died.

Scientists have used plasma from COVID-19 recovered patients to treat some mice. Some were injected with it before infection, others after. In the first case, antibodies prevented the spread of the virus, in the second, they stopped its advance by about the third day. However, not all antibodies were effective. Those who didn’t perform well in their effector function - the ability to “call for help” from other cells in the immune system and destroy infected cells - were less successful. “Antibodies must be present in the body at the right time, in the right place and in the right amount. Neutralizing activity alone is not enough without an effector function,”summed up one of the authors of the work, assistant professor at the Yale School of Medicine Priti Kumar.

Scientists emphasize that the results of their research can be applied in the treatment of COVID-19.

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